A flood alert is in place for the River Thame and Chalgrove Brook.
Those living near Thame, Long Marston, Shabbington and Ickford are being warned to be prepared by the Environment Agency.
There are currently 55 flood alerts in place across the region and more heavy rain is expected in the coming days.
Alison Baptiste, from the Environment Agency, said: “It looks like it’s going to be wet for the rest of the week and into this weekend, with rain forecast across the region for the next five days.
“Our teams are working hard to prepare and to make sure our professional partners are prepared.
“We have officers out checking flood defences and clearing any river blockages. We are receiving regular updates from the Met Office and will continuously monitor river levels.
“Now is a good time for anyone who lives in an area vulnerable to flooding to think about the precautions they can take to protect their properties, and we strongly urge people to sign up to flood warnings, keep a close eye on local weather forecasts.
“We also ask that people stay safe, by staying away swollen rivers and not attempting to drive through floodwater or taking their boats on to rivers.”