Police are concerned for the welfare of a missing man known to suffer from depression.
Richard Harris, who lives near Thame, was last seen at his home at 2pm yesterday.
The 39-year-old Little Milton resident is white, 6ft tall, of a heavy build and bald at the top of his head with brown hair on the sides. When he was last seen he is said to have been wearing a T-shirt, blue jeans and possibly a blue fleece.
Mr Harris, who takes medication for his condition, is also believed to have a suitcase, a duvet and pillows with him.
He has links to Bicester and has been known to frequent KFC in Woodstock Road, Oxford, and the Welcome Break at Waterstock.
Police are appealing for anyone with information to call 101.