The first phase of the work is due to take place on Friday, July 5.
Work will take place between the roundabout that leads to Aston Clinton and Tring Hill.
The southbound carriageway out of Aylesbury will be closed from 7.30pm and both sides will be closed from 10pm until 6am.
Bucks County Council said it is doing the work to improve the condition of the road to prolong its life.
The work is weather dependent and may be subject to disruption.
The council said: “The decision has been made to carry out this phase of the works at night to minimise large scale disruption during the day.
“In order to minimise the impact on residents, Transport for Bucks will endeavour to keep the noise levels on the site as low as reasonably possible at all times.
“However, due to the nature of these works, noisy activities may occur at times throughout the period and Transport for Bucks apologise in advance for this.
“Every effort will be made to maintain access for residents, although there may be some delay as the road treatment works pass individual properties.”
The second phase of the work will be carried out in early to mid July and involves a surface dressing treatment being applied to the carriageway.
Advance warning boards will be put on site stating dates and durations before this starts.
A daytime road closure will be needed for this work, which is expected to take one day.
There will be a temporary road surface in the interim period.
To find out more visit the council website.