Explosions were heard in Aston Clinton after a garage fire broke out on Friday night.
A car and a number of cylinders were in the London Road garage, which was destroyed by the fire.
The adjoining home was partially damaged by heat and smoke but no one is known to have been injured.
Four fire crews from Aylesbury and Tring rushed to the scene after the fire started at around 7.14pm.
They used two jets and a hose reel to put out the inferno.
The road was closed to traffic while firefighters dealt with the incident.